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Thyroid Nodule ICD 10 Code Update

Coding & Billing Solutions > Blog > ICD 10 Codes > Thyroid Nodule ICD 10 Code Update

Thyroid Nodule ICD 10 Code Update

2025 ICD-10-CM Diagnosis Code E04.1 Thyroid Nodule ICD 10 Code Update

Nontoxic single thyroid nodule

  • E04.1 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
  • The 2025 edition of ICD-10-CM E04.1 became effective on October 1, 2024.
  • This is the American ICD-10-CM version of E04.1 – other international versions of ICD-10 E04.1 may differ.

Applicable To:

  • Colloid nodule (cystic) (thyroid)
  • Nontoxic uninodular goiter
  • Thyroid (cystic) nodule NOS

The following code(s) above E04.1 contain annotation back-references that may be applicable to E04.1:

  • E00-E89
  • Endocrine, nutritional and metabolic diseases
  • E04
  • Other nontoxic goiter

Approximate Synonyms:

  • Cyst of thyroid
  • Dominant nodule of thyroid
  • Dominant thyroid nodule
  • Functioning thyroid nodule
  • Non-toxic uninodular goiter
  • Thyroid cyst
  • Thyroid goiter, nontoxic, uninodular
  • Thyroid nodule
  • Thyroid nodule, functioning

ICD-10-CM E04.1 is grouped within Diagnostic Related Group(s) (MS-DRG v42.0):

  • 011 Tracheostomy for face, mouth and neck diagnoses or laryngectomy with mcc
  • 012 Tracheostomy for face, mouth and neck diagnoses or laryngectomy with cc
  • 013 Tracheostomy for face, mouth and neck diagnoses or laryngectomy without cc/mcc
  • 643 Endocrine disorders with mcc
  • 644 Endocrine disorders with cc
  • 645 Endocrine disorders without cc/mcc

Convert E04.1 to ICD-9-CM

Thyroid Nodule ICD 10 Code History:

  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change
  • 2021 (effective 10/1/2020): No change
  • 2022 (effective 10/1/2021): No change
  • 2023 (effective 10/1/2022): No change
  • 2024 (effective 10/1/2023): No change
  • 2025 (effective 10/1/2024): No change

Diagnosis Index entries containing back-references to E04.1:

  • Colloid nodule E04.1 (of thyroid) (cystic)
  • Cyst (colloid) (mucous) (simple) (retention)

        thyroid E04.1 (gland)

  • Goiter (plunging) (substernal) E04.9

        nontoxic E04.9

            uninodular E04.1

        uninodular (nontoxic) E04.1

  • Nodule(s)

        thyroid (cold) (gland) (nontoxic) E04.1

        colloid E04.1 (cystic)

  • Struma – see also Goiter

        nodosa (simplex) E04.9

            uninodular E04.1

  • Thyroid (gland) (body) – see also condition

        nodule E04.1 (cystic) (nontoxic) (single)

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.

If you need more information about Thyroid Nodule ICD 10 code updates or just want to learn more about medical coding and HIM solutions from Coding & Billing Solutions, contact us today.