Multiple Myeloma ICD 10 Codes

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Multiple Myeloma ICD 10 Codes

The 2024 edition of ICD-10-CM C90.00 became effective on October 1, 2023.

This is the American ICD-10-CM version of C90.00 – other international versions of ICD-10 C90.00 may differ.

These codes are applicable to:

  1. Multiple myeloma with failed remission
  2. Multiple myeloma NOS

The following code(s) above C90.00 contain annotation back-references that may be applicable to C90.00:

C00-D49 – Neoplasms

C81-C96 – Malignant neoplasms of lymphoid, hematopoietic and related tissue

C90 – Multiple myeloma and malignant plasma cell neoplasms

C90.0 – Multiple myeloma

Approximate Synonyms

  • Hypogammaglobulinemia co-occurrent and due to multiple myeloma
  • Light chain disease
  • Light chain nephropathy
  • Light chain nephropathy due to multiple myeloma
  • Multiple myeloma
  • Multiple myeloma stage i
  • Multiple myeloma stage ii
  • Multiple myeloma stage iii
  • Multiple myeloma w hypogammaglobulinemia
  • Smoldering multiple myeloma
  • Smoldering myeloma

Clinical Information

  • A bone marrow-based plasma cell neoplasm characterized by a serum monoclonal protein and skeletal destruction with osteolytic lesions, pathological fractures, bone pain, hypercalcemia, and anemia. Clinical variants include non-secretory myeloma, smoldering myeloma, indolent myeloma, and plasma cell leukemia. (who, 2001)
  • A malignancy of mature plasma cells engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess bence-jones proteins (free monoclonal immunoglobulin light chains) in the urine, skeletal destruction, bone pain, and fractures. Other features include anemia; hypercalcemia; and renal insufficiency.
  • A malignant neoplasm of the bone marrow composed of plasma cells.
  • A type of cancer that begins in plasma cells (white blood cells that produce antibodies).
  • Malignant neoplasm of plasma cells usually arising in the bone marrow and manifested by skeletal destruction, bone pain, and the presence of anomalous immunoglobulins.
  • Multiple myeloma is a cancer that begins in plasma cells, a type of white blood cell. These cells are part of your immune system, which helps protect the body from germs and other harmful substances. In time, myeloma cells collect in the bone marrow and in the solid parts of bone.no one knows the exact causes of multiple myeloma, but it is more common in older people and african-americans. Early symptoms may include:
  • bone pain, often in the back or ribs
  • broken bones
  • weakness or fatigue
  • weight loss
  • repeated infections

myeloma is hard to cure. Treatment may help control symptoms and complications. Options include chemotherapy, stem cell transplantation and radiation.

ICD-10-CM C90.00 is grouped within Diagnostic Related Group(s) (MS-DRG v41.0):

  • 820 Lymphoma and leukemia with major o.r. Procedures with mcc
  • 821 Lymphoma and leukemia with major o.r. Procedures with cc
  • 822 Lymphoma and leukemia with major o.r. Procedures without cc/mcc
  • 823 Lymphoma and non-acute leukemia with other procedures with mcc
  • 824 Lymphoma and non-acute leukemia with other procedures with cc
  • 825 Lymphoma and non-acute leukemia with other procedures without cc/mcc
  • 840 Lymphoma and non-acute leukemia with mcc
  • 841 Lymphoma and non-acute leukemia with cc
  • 842 Lymphoma and non-acute leukemia without cc/mcc

Convert C90.00 to ICD-9-CM

Code History

  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change
  • 2021 (effective 10/1/2020): No change
  • 2022 (effective 10/1/2021): No change
  • 2023 (effective 10/1/2022): No change
  • 2024 (effective 10/1/2023): No change

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.

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